2013-10-12 · Development of Dedicated dGEMRIC Protocol for Biochemical Imaging of the Temporomandibular Joint Disc at 3 Tesla: A Feasibility Study 1,3 P. Szomolányi, 1,2 E. Pittschieler, 1,3 V. Juráš, 3 I. Frollo, 1S. Trattnig 1MR Centre – High Field MR, Medical University of Vienna, Vienna, Austria

The dGEMRIC index was assessed on MRI according to established protocol. Regression analysis adjusted for age, sex, body mass index (BMI), and pres-.

Keywords: dGEMRIC Cartilage Regeneration 2010-11-01 · A standardized protocol was used for dGEMRIC 17, 24: after the intra-venous (iv) administration of the contrast agent (0.2 mM/kg Gd-DTPA 2−; Magnevist, Berlex Laboratories, Wayne, New Jersey) patients walked for 15 min to ensure the distribution into cartilage. The scans were obtained minimum of 30 min after administration. The delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC) method allows for both qualitative and quantitative measurement of the spatial distribution of glycosaminoglycan concentration [GAG] in cartilage, and has been used as a nondestructive surrogate for toluidine blue or saffranin O histological staining. degeneration on conventional MRI, reproducibility, and correlation with dGEMRIC JaspervanTiel & GyulaKotek & MaxReijman & PieterK.Bos & EstherE.Bron & StefanKlein & Materials and methods: MRI was performed on a whole-body 7.0 T MR scanner using a dedicated circular polarization knee coil. The protocol consisted of an inversion recovery sequence for dGEMRIC, a multiecho spin-echo sequence for standard T2 mapping, a gradient-echo sequence for T2* mapping and a morphologic PD SPACE sequence.

Different parameters have been proposed to acquire the data based on T1-weighting such as STIR imaging, saturation recovery, fast mapping, Look-Locker and driven equilibrium NMH MRI Protocols Hip dGEMRIC (revised July 2013) Contrast dose .4ml/kg Magnevist (check with MSK attending is eGFR is >60) Magnevist is the only agent that can be used for cartilage imaging because of its -2 charge Magnevist distributes in cartilage in an inversely proportional manner to the concentration of The following general protocol is currently suggested for dGEMRIC: intravenous injection of a double dose of Gd(DTPA) 2–, followed by 10 min of exercise of the joint, and MRI of T 1 2–3 hr post‐injection for the knee or 30–90 min for the hip. Conclusions: The dGEMRIC MRI protocol is a useful method to evaluate cartilage repair. In addition, local cartilage repair inﬂuenced the cartilage quality at other location in the joint. These ﬁndings validate the use of dGEMRIC for non-invasive evaluation of the effects of cartilage regeneration. 2013 Osteoarthritis Research Society International. title = "Protocol issues for delayed Gd (DTPA)2--enhanced MRI (dGEMRIC) for clinical evaluation of articular cartilage", abstract = "Biochemical and histologic data have validated the technique of delayed gadolinium-enhanced MRI, in which the T1 values of cartilage after penetration of Gd (DTPA)2- allow assessment of the glycosaminoglycan (GAG) component of articular cartilage. abstract = "Objective Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) facilitates non-invasive evaluation of the glycosaminoglycan content in articular cartilage.

This study evaluates dGEMRIC in patients Conclusion: Because dGEMRIC protocol elements resulted in only small differences in T2 relaxation times that were not consistent and lower than the SDC in the majority of regions, our results suggest that T2-mapping and dGEMRIC can be performed reliably in a single imaging session to assess cartilage biochemical composition in knee osteoarthritis (OA) at 3 T. Compositional MRI techniques have the potential to become markers of the incidence and progression of OA, especially in the earliest stages of disease and could be useful in clinical trials when testing disease-modifying OA drugs.10, 11 Before dGEMRIC can be validated as a marker, an association must be shown between worsening of the dGEMRIC index and morphological changes over time.

The following general protocol is currently suggested for dGEMRIC: intravenous injection of a double dose of Gd (DTPA) 2–, followed by 10 min of exercise of the joint, and MRI of T1 2–3 hr post‐injection for the knee or 30–90 min for the hip. This method has reproducibility for T1 of better than 15%.

3D delayed gadolinium-enhanced MRI of cartilage. (dGEMRIC) at 3T used to evaluate the effect of hyaluronic acid on cartilage 504 for MR and protocol).

CONCLUSION Because dGEMRIC protocol elements resulted in only small differences in T2 relaxation times that were not consistent and lower than the SDC in the majority of regions, our results suggest that T2-mapping and dGEMRIC can be performed reliably in a single imaging session to assess cartilage biochemical composition in knee osteoarthritis (OA) at 3 T.

2013-07-01 · The dGEMRIC MRI protocol is a useful method to evaluate cartilage repair. In addition, local cartilage repair influenced the cartilage quality at other location in the joint. These findings validate the use of dGEMRIC for non-invasive evaluation of the effects of cartilage regeneration.

The patients were Delayed Gadolinium-Enhanced MRI of Cartilage (dGEMRIC) in Early Knee Osteoarthritis Carl Johan Tiderius, Lars E. Olsson, Peter Leander, Olle Ekberg, and Leif Dahlberg* Delayed contrast-enhanced MRI of cartilage (dGEMRIC) is a noninvasive technique to study cartilage glycosaminoglycan (GAG) content in vivo. This study evaluates dGEMRIC in patients Conclusion: Because dGEMRIC protocol elements resulted in only small differences in T2 relaxation times that were not consistent and lower than the SDC in the majority of regions, our results suggest that T2-mapping and dGEMRIC can be performed reliably in a single imaging session to assess cartilage biochemical composition in knee osteoarthritis (OA) at 3 T. Compositional MRI techniques have the potential to become markers of the incidence and progression of OA, especially in the earliest stages of disease and could be useful in clinical trials when testing disease-modifying OA drugs.10, 11 Before dGEMRIC can be validated as a marker, an association must be shown between worsening of the dGEMRIC index and morphological changes over time.
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When the technique is adapted and applied to menisci it is called dGEMRIM. Abstract. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was first described in 1996 as a nondestructive technique for quantitative measurements of glycosaminoglycan (GAG) concentration in articular cartilage samples [1]. Its translation to clinical platforms as a means of interrogating the molecular aspects of cartilage was demonstrated in diffusion of the contrast agent into the cartilage.

Magn Reson Med 2001;45(1):36-41. Tiderius dGEMRIC, or delayed gadolinium-enhanced MRI of cartilage is a technique that can be used quantitatively to assess glycosaminoglycan content of cartilage or qualitatively to asses the overall structures of cartilage.
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Abstract. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was first described in 1996 as a nondestructive technique for quantitative measurements of glycosaminoglycan (GAG) concentration in articular cartilage samples [1]. Its translation to clinical platforms as a means of interrogating the molecular aspects of cartilage was demonstrated in

Its translation to clinical platforms as a means of interrogating the molecular aspects of cartilage was demonstrated in diffusion of the contrast agent into the cartilage. dGEMRIC imaging started 75 minutes after injection. qMRI Protocol: 3D sagittal fast gradient echo with selective water excitation (ProSet), TR/TE/flip = 18.5 ms/6.3 ms/15 º, FOV = 160 mm, matrix: 512 x 512, 1.5 mm slice thickness, 50 slices, 6:45 minutes. Delayed contrast-enhanced MRI of cartilage (dGEMRIC) is a noninvasive technique to study cartilage glycosaminoglycan (GAG) content in vivo.